Article
Genetic variations in toll-like receptor pathway genes influence asthma and atopy.
Allergy - 1 Mar 2011
Tesse R, Pandey R C, Kabesch M
Abstract excerpt
Innate immunity is a pivotal defence system of higher organisms. Based on a limited number of receptors, it is capable of recognizing pathogens and to initiate immune responses. Major components of these innate immunity pathogen recognition receptors are the toll-like receptors (TLRs), a family of 11 in humans. They are all membrane bound and through dimerization and complex downstream signaling, TLRs elicit a...
Topics
- Asthma
- Environment
- Genetic Variation
- Humans
- Hypersensitivity
- Immunity, Innate
- Lipopolysaccharide Receptors
- Signal Transduction
- Toll-Like Receptors