Article
An association study of asthma and total serum immunoglobin E levels for Toll‐like receptor polymorphisms in a Japanese population
1 Feb 2004
Abstract excerpt
BACKGROUND: The prevalence of atopic diseases has been increasing in developed countries. This could be explained by the hygiene hypothesis, which states that exposure to specific infections or endotoxins during infancy drives the maturing immune system towards a Th1 phenotype and away from the Th2 phenotype, which is associated with allergic diseases. Toll-like receptors (TLRs) play important roles in the...
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