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Article

Bifunctional killing activity encoded by conserved reaper proteins.

Cell death and differentiation - 1 Jul 2004

Chen P, Ho S-I, Shi Z, Abrams J M

Abstract excerpt

Drosophila activators of apoptosis mapping to the Reaper region function, in part, by antagonizing IAP proteins through a shared RHG motif. We isolated Reaper from the Blowfly L. cuprina, which triggered extensive apoptosis in Drosophila cells. Conserved regions of Reaper were tested in the context of GFP fusions and a second killing activity, distinct from the RHG, was identified. A 20 amino-acid peptide,...

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Identifiers

PMID: 15002042
DOI: 10.1038/sj.cdd.4401406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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