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Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.

Cell death and differentiation - 1 Mar 2012

Domingues C, Ryoo H D

Abstract excerpt

Active caspases execute apoptosis to eliminate superfluous or harmful cells in animals. In Drosophila, living cells prevent uncontrolled caspase activation through an inhibitor of apoptosis protein (IAP) family member, dIAP1, and apoptosis is preceded by the expression of IAP-antagonists, such as Reaper, Hid and Grim. Strong genetic modifiers of this pathway include another IAP family gene encoding an E2...

Topics

Amino Acid Motifs
Animals
Apoptosis
Drosophila Proteins
Drosophila melanogaster
Inhibitor of Apoptosis Proteins
Mutation
Ubiquitin
Ubiquitination

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Identifiers

PMID: 21886178
DOI: 10.1038/cdd.2011.116
PMCID: PMC3235231

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Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.PMID 21886178Read ↗

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