Article
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.
Nature cell biology - 1 Sept 2002
Kuranaga Erina, Kanuka Hirotaka, Igaki Tatsushi, Sawamoto Kazunobu, Ichijo Hidenori, Okano Hideyuki, Miura Masayuki
Abstract excerpt
Although Jun amino-terminal kinase (JNK) is known to mediate a physiological stress signal that leads to cell death, the exact role of the JNK pathway in the mechanisms underlying intrinsic cell death is largely unknown. Here we show through a genetic screen that a mutant of Drosophila melanogaster tumour-necrosis factor receptor-associated factor 1 (DTRAF1) is a dominant suppressor of Reaper-induced cell death....
Topics
- Animals
- Animals, Genetically Modified
- Apoptosis
- Base Sequence
- Drosophila Proteins
- Drosophila melanogaster
- Enzyme Activation
- Eye
- Genes, Insect
- Inhibitor of Apoptosis Proteins
- JNK Mitogen-Activated Protein Kinases
- MAP Kinase Kinase Kinase 5
- MAP Kinase Kinase Kinases