Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function.

The EMBO journal - 15 Feb 2000

Goyal L, McCall K, Agapite J, Hartwieg E, Steller H

Abstract excerpt

Induction of apoptosis in Drosophila requires the activity of three closely linked genes, reaper, hid and grim. Here we show that the proteins encoded by reaper, hid and grim activate cell death by inhibiting the anti-apoptotic activity of the Drosophila IAP1 (diap1) protein. In a genetic modifier screen, both loss-of-function and gain-of-function alleles in the endogenous diap1 gene were obtained, and the mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Eye
Share to Genes, Insect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Inhibitor of Apoptosis Proteins

Share to Insect Proteins

Share to Microscopy, Electron, Scanning

Share to Neuropeptides

Share to Peptides

Source

Open in PubMed Open full text

Identifiers

PMID: 10675328
DOI: 10.1093/emboj/19.4.589
PMCID: PMC305597

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function.PMID 10675328Read ↗

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.Semantic proximity Read ↗

The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers.Semantic proximity Read ↗

Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila.Semantic proximity Read ↗

Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.Semantic proximity Read ↗

Bifunctional killing activity encoded by conserved reaper proteins.Semantic proximity Read ↗

sickle, a Novel Drosophila Death Gene in the reaper/hid/grim Region, Encodes an IAP-Inhibitory ProteinSemantic proximity Read ↗

Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms.Semantic proximity Read ↗

The RHG motifs of Drosophila Reaper and Grim are important for their distinct cell death-inducing abilities.Semantic proximity Read ↗

Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.Semantic proximity Read ↗

Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila.Semantic proximity Read ↗

The Damage-Responsive Drosophila Gene sickle Encodes a Novel IAP Binding Protein Similar to but Distinct from reaper, grim, and hidSemantic proximity Read ↗

Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.