Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.

Nature structural & molecular biology - 1 May 2004

Yan Nieng, Wu Jia-Wei, Chai Jijie, Li Wenyu, Shi Yigong

Abstract excerpt

The Drosophila melanogaster inhibitor of apoptosis protein DIAP1 suppresses apoptosis in part through inhibition of the effector caspase DrICE. The pro-death proteins Reaper, Hid and Grim (RHG) induce apoptosis by antagonizing DIAP1 function. However, the underlying molecular mechanisms remain unknown. Here we demonstrate that DIAP1 directly inhibits the catalytic activity of DrICE through its BIR1 domain and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caspase Inhibitors
Share to Caspases
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Inhibitor of Apoptosis Proteins

Share to Models, Molecular

Share to Neuropeptides

Share to Protein Conformation

Source

Identifiers

PMID: 15107838
DOI: 10.1038/nsmb764

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.PMID 15107838Read ↗

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function.Semantic proximity Read ↗

The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers.Semantic proximity Read ↗

Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila.Semantic proximity Read ↗

Control of apoptosis by Drosophila DCAF12.Semantic proximity Read ↗

Drosophila BRUCE inhibits apoptosis through non-lysine ubiquitination of the IAP-antagonist REAPER.Semantic proximity Read ↗

The RHG motifs of Drosophila Reaper and Grim are important for their distinct cell death-inducing abilities.Semantic proximity Read ↗

Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila.Semantic proximity Read ↗

Cleavage of the apoptosis inhibitor DIAP1 by the apical caspase DRONC in both normal and apoptotic Drosophila cells.Semantic proximity Read ↗

Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms.Semantic proximity Read ↗

Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.Semantic proximity Read ↗

Bifunctional killing activity encoded by conserved reaper proteins.Semantic proximity Read ↗

The Drosophila caspase DRONC is regulated by DIAP1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.