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Article

A combination of mutations in the S1 part of the spike glycoprotein gene of coronavirus MHV-A59 abolishes demyelination.

Journal of neurovirology - 1 Feb 2004

Fu Li, Gonzales Donna M, Das Sarma Jayasri, Lavi Ehud

Abstract excerpt

The A59 strain of coronavirus, mouse hepatitis virus (MHV), produces acute hepatitis, meningoencephalitis, and chronic demyelination. The authors have previously shown that the spike (S) glycoprotein gene of MHV contains determinants of virulence, hepatitis, and demyelination. They then identified viruses containing mutations in the S gene that exhibit alterations in viral pathogenesis. In the present study, the...

Topics

Animals
Brain
Coronavirus Infections
Demyelinating Diseases
Hepatitis, Viral, Animal
Liver
Membrane Glycoproteins
Mice
Murine hepatitis virus
Mutagenesis, Site-Directed
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Reverse Transcriptase Polymerase Chain Reaction

Spike Glycoprotein, Coronavirus

Spinal Cord

Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 14982727
DOI: 10.1080/13550280490262229
PMCID: PMC7095319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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