Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered pathogenesis of a mutant of the murine coronavirus MHV-A59 is associated with a Q159L amino acid substitution in the spike protein.

Virology - 8 Dec 1997

Leparc-Goffart I, Hingley S T, Chua M M, Jiang X, Lavi E, Weiss S R

Abstract excerpt

C12, an attenuated, fusion delayed, very weakly hepatotropic mutant of mouse hepatitis virus strain A59 (MHV-A59( has been further characterized. We have previously shown that C12 has two amino acid substitutions relative to wild type virus in the spike protein, Q159L (within a region of S1 shown to bind to viral receptor in an in vitro assay) and H716D (in the proteolytic cleavage recognition site). We have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Coronavirus Infections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Glycoproteins

Share to Murine hepatitis virus

Share to Mutation

Share to Viral Envelope Proteins

Share to Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 9426441
DOI: 10.1006/viro.1997.8877
PMCID: PMC7131600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Altered pathogenesis of a mutant of the murine coronavirus MHV-A59 is associated with a Q159L amino acid substitution in the spike protein.PMID 9426441Read ↗

The C12 mutant of MHV-A59 is very weakly demyelinating and has five amino acid substitutions restricted to the spike and replicase genes.Semantic proximity Read ↗

MHV-A59 fusion mutants are attenuated and display altered hepatotropism.Semantic proximity Read ↗

Hepatitis mutants of mouse hepatitis virus strain A59.Semantic proximity Read ↗

A combination of mutations in the S1 part of the spike glycoprotein gene of coronavirus MHV-A59 abolishes demyelination.Semantic proximity Read ↗

Fusion-defective mutants of mouse hepatitis virus A59 contain a mutation in the spike protein cleavage signal.Semantic proximity Read ↗

Identification of peplomer cleavage site mutations arising during persistence of MHV-A59.Semantic proximity Read ↗

Enhanced Virulence Mediated by the Murine Coronavirus, Mouse Hepatitis Virus Strain JHM, Is Associated with a Glycine at Residue 310 of the Spike GlycoproteinSemantic proximity Read ↗

Murine Coronavirus Spike Protein Determines the Ability of the Virus To Replicate in the Liver and Cause HepatitisSemantic proximity Read ↗

Variations in disparate regions of the murine coronavirus spike protein impact the initiation of membrane fusion.Semantic proximity Read ↗

A conditional-lethal murine coronavirus mutant that fails to incorporate the spike glycoprotein into assembled virions.Semantic proximity Read ↗

Demyelination Determinants Map to the Spike Glycoprotein Gene of Coronavirus Mouse Hepatitis VirusSemantic proximity Read ↗

Sequence analysis of the spike protein gene of murine coronavirus variants: study of genetic sites affecting neuropathogenicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.