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Article

Amino acid substitutions within the heptad repeat domain 1 of murine coronavirus spike protein restrict viral antigen spread in the central nervous system.

Virology - 1 Aug 2003

Tsai Jean C, de Groot Linda, Pinon Josefina D, Iacono Kathryn T, Phillips Joanna J, Seo Su-hun, Lavi Ehud, Weiss Susan R

Abstract excerpt

Targeted recombination was carried out to select mouse hepatitis viruses (MHVs) in a defined genetic background, containing an MHV-JHM spike gene encoding either three heptad repeat 1 (HR1) substitutions (Q1067H, Q1094H, and L1114R) or L1114R alone. The recombinant virus, which expresses spike with the three substitutions, was nonfusogenic at neutral pH. Its replication was significantly inhibited by...

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Identifiers

PMID: 12919742
DOI: 10.1016/s0042-6822(03)00248-4
PMCID: PMC7125853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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