Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Demyelination Determinants Map to the Spike Glycoprotein Gene of Coronavirus Mouse Hepatitis Virus

1 Oct 2000

Abstract excerpt

Demyelination is the pathologic hallmark of the human immune-mediated neurologic disease multiple sclerosis, which may be triggered or exacerbated by viral infections. Several experimental animal models have been developed to study the mechanism of virus-induced demyelination, including coronavirus mouse hepatitis virus (MHV) infection in mice. The envelope spike (S) glycoprotein of MHV contains determinants of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to Viral gastroenteritis research and epidemiology
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10982367
DOI: 10.1128/jvi.74.19.9206-9213.2000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Demyelination Determinants Map to the Spike Glycoprotein Gene of Coronavirus Mouse Hepatitis VirusPMID 10982367Read ↗

A combination of mutations in the S1 part of the spike glycoprotein gene of coronavirus MHV-A59 abolishes demyelination.Semantic proximity Read ↗

The genetics of the persistent infection and demyelinating disease caused by Theiler's virus.Semantic proximity Read ↗

Enhanced Virulence Mediated by the Murine Coronavirus, Mouse Hepatitis Virus Strain JHM, Is Associated with a Glycine at Residue 310 of the Spike GlycoproteinSemantic proximity Read ↗

The spike protein of murine coronavirus regulates viral genome transport from the cell surface to the endoplasmic reticulum during infection.Semantic proximity Read ↗

Sequence analysis of the spike protein gene of murine coronavirus variants: study of genetic sites affecting neuropathogenicity.Semantic proximity Read ↗

Evolution of mouse hepatitis virus (MHV) during chronic infection: quasispecies nature of the persisting MHV RNA.Semantic proximity Read ↗

Mouse Hepatitis Virus Infection of the Central Nervous System: Chemokine-Mediated Regulation of Host Defense and DiseaseSemantic proximity Read ↗

Expression of Hemagglutinin Esterase Protein from Recombinant Mouse Hepatitis Virus Enhances NeurovirulenceSemantic proximity Read ↗

Evolution of mouse hepatitis virus: detection and characterization of spike deletion variants during persistent infection.Semantic proximity Read ↗

Murine Coronavirus Spike Protein Determines the Ability of the Virus To Replicate in the Liver and Cause HepatitisSemantic proximity Read ↗

SJL/J resistance to mouse hepatitis virus-JHM-induced neurologic disease can be partially overcome by viral variants of S and host immunosuppression.Semantic proximity Read ↗

The role of myelin in Theiler's virus persistence in the central nervous system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.