Article
Sequence analysis of the spike protein gene of murine coronavirus variants: study of genetic sites affecting neuropathogenicity.
Virology - 1 Feb 1992
Wang F I, Fleming J O, Lai M M
Abstract excerpt
Mouse hepatitis virus (MHV), a coronavirus, causes encephalitis and demyelination in susceptible rodents. Previous investigations have shown that the MHV spike (S) protein is a critical determinant of viral tropism and pathogenicity in mice and rats. To understand the molecular basis of MHV neuro...
Topics
- Animals
- Antibodies, Monoclonal
- Base Sequence
- Central Nervous System Diseases
- Cloning, Molecular
- Coronaviridae
- Coronaviridae Infections
- Genetic Variation
- Membrane Glycoproteins
- Mice
- Neutralization Tests
- Spike Glycoprotein, Coronavirus
- Tumor Cells, Cultured
- Viral Envelope Proteins