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Article

MHV-A59 fusion mutants are attenuated and display altered hepatotropism.

Virology - 1 Apr 1994

Hingley S T, Gombold J L, Lavi E, Weiss S R

Abstract excerpt

Mouse hepatitis virus strain A59 causes a persistent productive, but nonlytic, infection of cultured glial cells. We have mutants isolated from persistently infected glial cell cultures which have been shown to be fusion-defective due to a histidine to aspartic acid mutation (H716D) near the cleavage site of the peplomer protein, S. Here, we examine the pathogenicity of these mutants and show differences in...

Topics

Amino Acid Sequence
Animals
Antigens, Viral
Brain
Coronavirus Infections
Demyelinating Diseases
Liver
Membrane Fusion
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Murine hepatitis virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neuroglia

Organ Specificity

Viral Proteins

Virulence

Source

Identifiers

PMID: 8128613
DOI: 10.1006/viro.1994.1156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8128613-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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