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Article

MHV-A59 fusion mutants are attenuated and display altered hepatotropism.

Virology - 1 Apr 1994

Hingley S T, Gombold J L, Lavi E, Weiss S R

Abstract excerpt

Mouse hepatitis virus strain A59 causes a persistent productive, but nonlytic, infection of cultured glial cells. We have mutants isolated from persistently infected glial cell cultures which have been shown to be fusion-defective due to a histidine to aspartic acid mutation (H716D) near the cleavage site of the peplomer protein, S. Here, we examine the pathogenicity of these mutants and show differences in...

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PMID: 8128613
DOI: 10.1006/viro.1994.1156

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