Article
Hepatitis mutants of mouse hepatitis virus strain A59.
Advances in experimental medicine and biology - 1 Jan 1995
Hingley S T, Gombold J L, Lavi E, Weiss S R
Abstract excerpt
MHV-A59 causes acute meningoencephalitis and hepatitis in susceptible mice, and a persistent productive, but nonlytic, infection of cultured glial cells. We have shown previously that viruses isolated from persistently infected glial cell cultures have a fusion-defective phenotype and were impaired in their abilities to cause hepatitis compared to wild-type MHV-A59. Two mutants chosen for detailed study, B11 and...
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