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Article

Variations in disparate regions of the murine coronavirus spike protein impact the initiation of membrane fusion.

Journal of virology - 1 Mar 2001

Krueger D K, Kelly S M, Lewicki D N, Ruffolo R, Gallagher T M

Abstract excerpt

The prototype JHM strain of murine hepatitis virus (MHV) is an enveloped, RNA-containing coronavirus that has been selected in vivo for extreme neurovirulence. This virus encodes spike (S) glycoproteins that are extraordinarily effective mediators of intercellular membrane fusion, unique in their ability to initiate fusion even without prior interaction with the primary MHV receptor, a murine carcinoembryonic...

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Source

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Identifiers

PMID: 11222703
DOI: 10.1128/JVI.75.6.2792-2802.2001
PMCID: PMC115904

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Source receipt: pubmed, retrieved 7 Sept 2026.

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