The C12 mutant of MHV-A59 is very weakly demyelinating and has five amino acid substitutions restricted to the spike and replicase genes.

doi:10.1007/978-1-4615-5331-1_81

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Article

The C12 mutant of MHV-A59 is very weakly demyelinating and has five amino acid substitutions restricted to the spike and replicase genes.

Advances in experimental medicine and biology - 1 Jan 1998

Leparc-Goffart I, Hingley S T, Jiang X, Chua M M, Lavi E, Weiss S R

Abstract excerpt

C12, an attenuated, fusion defective, very weakly hepatotropic mutant of MHV-A59 has been further characterized. Analysis of C12 in vivo in C57BL/6 mice has shown that despite the fact that this virus replicates in the brain to titers at least as high as wild type and causes acute encephalitis si...

Topics

Amino Acid Substitution
Animals
Demyelinating Diseases
Genome, Viral
Membrane Glycoproteins
Mice
Mice, Inbred C57BL
Murine hepatitis virus
Mutation
RNA-Dependent RNA Polymerase
Spike Glycoprotein, Coronavirus
Viral Envelope Proteins

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PMID: 9782338
DOI: 10.1007/978-1-4615-5331-1_81

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9782338-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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