Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of Hemagglutinin Esterase Protein from Recombinant Mouse Hepatitis Virus Enhances Neurovirulence

23 Nov 2005

Abstract excerpt

Murine hepatitis virus (MHV) infection provides a model system for the study of hepatitis, acute encephalitis, and chronic demyelinating disease. The spike glycoprotein, S, which mediates receptor binding and membrane fusion, plays a critical role in MHV pathogenesis. However, viral proteins other than S also contribute to pathogenicity. The JHM strain of MHV is highly neurovirulent and expresses a second spike...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to SARS-CoV-2 and COVID-19 Research
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16306577
DOI: 10.1128/jvi.79.24.15064-15073.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of Hemagglutinin Esterase Protein from Recombinant Mouse Hepatitis Virus Enhances NeurovirulencePMID 16306577Read ↗

Both Spike and Background Genes Contribute to Murine Coronavirus NeurovirulenceSemantic proximity Read ↗

Enhanced Virulence Mediated by the Murine Coronavirus, Mouse Hepatitis Virus Strain JHM, Is Associated with a Glycine at Residue 310 of the Spike GlycoproteinSemantic proximity Read ↗

Partial deletion in the spike endodomain of mouse hepatitis virus decreases the cytopathic effect but maintains foreign protein expression in infected cells.Semantic proximity Read ↗

Amino acid substitutions within the heptad repeat domain 1 of murine coronavirus spike protein restrict viral antigen spread in the central nervous system.Semantic proximity Read ↗

A combination of mutations in the S1 part of the spike glycoprotein gene of coronavirus MHV-A59 abolishes demyelination.Semantic proximity Read ↗

Variations in disparate regions of the murine coronavirus spike protein impact the initiation of membrane fusion.Semantic proximity Read ↗

Murine Coronavirus Spike Protein Determines the Ability of the Virus To Replicate in the Liver and Cause HepatitisSemantic proximity Read ↗

Hepatitis mutants of mouse hepatitis virus strain A59.Semantic proximity Read ↗

Demyelination Determinants Map to the Spike Glycoprotein Gene of Coronavirus Mouse Hepatitis VirusSemantic proximity Read ↗

The spike protein of murine coronavirus regulates viral genome transport from the cell surface to the endoplasmic reticulum during infection.Semantic proximity Read ↗

A role for naturally occurring variation of the murine coronavirus spike protein in stabilizing association with the cellular receptor.Semantic proximity Read ↗

Heterogeneity of gene expression of the hemagglutinin-esterase (HE) protein of murine coronaviruses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.