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Both Spike and Background Genes Contribute to Murine Coronavirus Neurovirulence

29 Jun 2006

Abstract excerpt

Various strains of mouse hepatitis virus (MHV) exhibit different pathogenic phenotypes. Infection with the A59 strain of MHV induces both encephalitis and hepatitis, while the highly neurovirulent JHM strain induces a fatal encephalitis with little, if any, hepatitis. The pathogenic phenotype for each strain is determined by the genetic composition of the viral genome, as well as the host immune response. Using...

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PMID: 16809289
DOI: 10.1128/jvi.00432-06

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