Article
Anti-P53 antibodies in Brazilian brain tumor patients.
Genetics and molecular research : GMR - 30 Jun 2003
Fonseca Renata Fragelli, Kawamura Márcia Tie, Oliveira José Antônio, Teixeira Anselmo, Alves Gilda, Carvalho Maria da Glória da Costa
Abstract excerpt
Gliomas of astrocytic origin are the most common primary brain tumors, accounting for over 40 to 50% of all central nervous system tumors. The TP53 tumor suppressor gene is the most frequently mutated gene found in human malignancies. A mutation of this gene can lead to an increased half-life of the resulting protein and loss of biological function. High levels of p53 have been detected in the serum of colon...
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