Article
Absence of p53 autoantibodies in sera from glioma patients.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 1995
Rainov N G, Dobberstein K U, Fittkau M, Bahn H, Holzhausen H J, Gantchev L, Burkert W
Abstract excerpt
Alteration of the tumor suppressor gene p53 is the most frequent genetic feature of human cancer and leads to over-expression and loss of function of the p53 protein in affected cells. Patients with many types of cancer, including breast, lung, and colon carcinoma, were shown to develop auto-immu...
Topics
- Adult
- Aged
- Amino Acid Substitution
- Astrocytoma
- Autoantibodies
- Brain Neoplasms
- Enzyme-Linked Immunosorbent Assay
- Female
- Frameshift Mutation
- Glioblastoma
- Glioma
- Humans
- Male
- Middle Aged
- Mutation
- Point Mutation
- Polymerase Chain Reaction
- Tumor Suppressor Protein p53