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Article

[Overexpression of p53 protein in gliomas].

No shinkei geka. Neurological surgery - 1 Feb 1994

Kikuchi T, Diserens A C, Hamou M F, de Tribolet N, van Meir E

Abstract excerpt

We analyzed the levels of p53 protein in 10 frozen astrocytoma specimens by using an ELISA kit. p53 protein was detected in seven of ten specimens, and ranged from 0.4 to 18.0ng/ml. To confirm that the p53 protein detected in this study actually represented mutations occurring within the p53 gene, we determined the nucleotide sequence in five of six positive cases, and in three of four negative cases. We...

Topics

Astrocytoma
Brain Neoplasms
DNA, Neoplasm
Enzyme-Linked Immunosorbent Assay
Genes, p53
Humans
Mutation
Polymerase Chain Reaction
Tumor Suppressor Protein p53

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8115006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8115006-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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