Article
Timing of p53 mutations during astrocytoma tumorigenesis.
Human molecular genetics - 1 Oct 1993
del Arco A, García J, Arribas C, Barrio R, Blázquez M G, Izquierdo J M, Izquierdo M
Abstract excerpt
Using a combination of polymerase chain reaction and single-strand conformation polymorphism techniques (PCR-SSCP) we have analyzed 78 brain tumor samples (70 primary and 8 metastatic) for the presence of mutations in the conserved regions of the Tp53 (tumor p53) gene. We have found that only two groups, gliomas (exclusively in astrocytomas) and metastases, displayed Tp53 mutations. Three of eight (37.5%)...
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