Timing of p53 mutations during astrocytoma tumorigenesis.

doi:10.1093/hmg/2.10.1687

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Article

Timing of p53 mutations during astrocytoma tumorigenesis.

Human molecular genetics - 1 Oct 1993

del Arco A, García J, Arribas C, Barrio R, Blázquez M G, Izquierdo J M, Izquierdo M

Abstract excerpt

Using a combination of polymerase chain reaction and single-strand conformation polymorphism techniques (PCR-SSCP) we have analyzed 78 brain tumor samples (70 primary and 8 metastatic) for the presence of mutations in the conserved regions of the Tp53 (tumor p53) gene. We have found that only two...

Topics

Adenocarcinoma
Alleles
Astrocytoma
Base Sequence
Brain Neoplasms
Chromosomes, Human, Pair 17
Colonic Neoplasms
DNA Mutational Analysis
DNA, Neoplasm
DNA, Single-Stranded
Genes, p53
Glioblastoma
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Polymorphism, Genetic
Time Factors

Source

Open in PubMed

Identifiers

PMID: 8268922
DOI: 10.1093/hmg/2.10.1687

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8268922-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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