Article
The humoral immune response to p53 in patients with hepatocellular carcinoma is specific for malignancy and independent of the alpha-fetoprotein status.
Hepatology (Baltimore, Md.) - 1 Sept 1993
Volkmann M, Müller M, Hofmann W J, Meyer M, Hagelstein J, Räth U, Kommerell B, Zentgraf H, Galle P R
Abstract excerpt
Recently, p53 gene aberrations have been recognized as a relevant factor in hepatocarcinogenesis, in tumors from both high-risk and low-risk areas. Because p53 gene mutations typically result in increased p53 levels in tumor cells, this cellular protein might become immunogenic during tumor devel...
Topics
- Adult
- Aged
- Antibodies
- Antibody Formation
- Biomarkers, Tumor
- Carcinoma, Hepatocellular
- Female
- Genes, p53
- Humans
- Liver Cirrhosis
- Liver Neoplasms
- Male
- Middle Aged
- Mutation
- Tumor Suppressor Protein p53
- alpha-Fetoproteins