Article
The humoral immune response to p53 in patients with hepatocellular carcinoma is specific for malignancy and independent of the alpha-fetoprotein status.
Hepatology (Baltimore, Md.) - 1 Sept 1993
Volkmann M, Müller M, Hofmann W J, Meyer M, Hagelstein J, Räth U, Kommerell B, Zentgraf H, Galle P R
Abstract excerpt
Recently, p53 gene aberrations have been recognized as a relevant factor in hepatocarcinogenesis, in tumors from both high-risk and low-risk areas. Because p53 gene mutations typically result in increased p53 levels in tumor cells, this cellular protein might become immunogenic during tumor development. To test this hypothesis, we have analyzed sera from 80 European patients with hepatocellular carcinoma for the...
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