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Article

DNA repair functions that control sensitivity to topoisomerase-targeting drugs.

Eukaryotic cell - 1 Feb 2004

Malik Mobeen, Nitiss John L

Abstract excerpt

DNA topoisomerases play critical roles in a wide range of cellular processes by altering DNA topology to facilitate replication, transcription, and chromosome segregation. Topoisomerases alter DNA topology by introducing transient DNA strand breaks that involve a covalent protein DNA intermediate. Many agents have been found to prevent the religation of DNA strand breaks induced by the enzymes, thereby converting...

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Identifiers

PMID: 14871939
DOI: 10.1128/EC.3.1.82-90.2004
PMCID: PMC329506

Genes

MRE11
RAD52

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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