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Article

Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.

Molecular cell - 16 Jan 2009

Hartsuiker Edgar, Neale Matthew J, Carr Antony M

Abstract excerpt

For a cancer cell to resist treatment with drugs that trap topoisomerases covalently on the DNA, the topoisomerase must be removed. In this study, we provide evidence that the Schizosaccharomyces pombe Rad32(Mre11) nuclease activity is involved in the removal of both Top2 from 5' DNA ends as well...

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Identifiers

PMID: 19150433
DOI: 10.1016/j.molcel.2008.11.021
PMCID: PMC2675033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19150433-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.PMID 19150433Read ↗

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adductsSemantic proximity Read ↗

DNA repair functions that control sensitivity to topoisomerase-targeting drugs.Semantic proximity Read ↗

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.Semantic proximity Read ↗

Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repair.Semantic proximity Read ↗

Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.Semantic proximity Read ↗

MRE11 Function in Response to Topoisomerase Poisons Is Independent of its Function in Double-Strand Break Repair in Saccharomyces cerevisiaeSemantic proximity Read ↗

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1Semantic proximity Read ↗

CDC45 and DPB11 are required for processive DNA replication and resistance to DNA topoisomerase I-mediated DNA damage.Semantic proximity Read ↗

The role of MRN in the S-phase DNA damage checkpoint is independent of its Ctp1-dependent roles in double-strand break repair and checkpoint signaling.Semantic proximity Read ↗

Trapped Topoisomerase II initiates formation of <i>de novo</i> duplications <i>via</i> the nonhomologous end-joining pathway in yeastSemantic proximity Read ↗

Sae2 controls Mre11 endo- and exonuclease activities by different mechanisms.Semantic proximity Read ↗

Fork pausing complex engages topoisomerases at the replisome.Semantic proximity Read ↗

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