Article
Light-independent phosphorylation of WHITE COLLAR-1 regulates its function in the Neurospora circadian negative feedback loop.
The Journal of biological chemistry - 29 Apr 2005
He Qiyang, Shu Hongjun, Cheng Ping, Chen She, Wang Lixin, Liu Yi
Abstract excerpt
Phosphorylation is a major regulatory mechanism controlling circadian clocks. In the Neurospora circadian clock, the PER-ARNT-SIM (PAS) domain-containing transcription factor, WHITE COLLAR (WC)-1, acts both as the blue light photoreceptor of the clock and as a positive element in the circadian negative feedback loop in constant darkness, by activating the transcription of the frequency (frq) gene. To understand...
Topics
- Amino Acid Sequence
- Binding Sites
- Blotting, Western
- Circadian Rhythm
- DNA-Binding Proteins
- Electrophoresis, Polyacrylamide Gel
- Epitopes
- Feedback, Physiological
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Light
- Mass Spectrometry
- Molecular Sequence Data