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Article

The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk.

Cancer research - 1 Feb 2004

Duguay Yannick, McGrath Monica, Lépine Johanie, Gagné Jean-François, Hankinson Susan E, Colditz Graham A, Hunter David J, Plante Marie, Têtu Bernard, Bélanger Alain, Guillemette Chantal, De Vivo Immaculata

Abstract excerpt

UDP-glucuronosyltransferase (UGT) 1A1 is involved in the inactivation of estradiol (E(2)) and its oxidized metabolites. These metabolites have been shown to contribute to the development of endometrial cancer in animal studies. Thus UGT1A1 represents a candidate gene in endometrial carcinogenesis. In this study, we established the substrate specificity of UGT1A1 for E(2) and its 2- and 4-hydroxylated metabolites....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14871858
DOI: 10.1158/0008-5472.can-03-3295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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