Article
A potential role for human UDP-glucuronosyltransferase 1A4 promoter single nucleotide polymorphisms in the pharmacogenomics of tamoxifen and its derivatives.
Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2014
Greer Aleksandra K, Dates Centdrika R, Starlard-Davenport Athena, Edavana Vineetha K, Bratton Stacie M, Dhakal Ishwori B, Finel Moshe, Kadlubar Susan A, Radominska-Pandya Anna
Abstract excerpt
Tamoxifen (Tam) is a selective estrogen receptor modulator used to inhibit breast tumor growth. Tam can be directly N-glucuronidated via the tertiary amine group or O-glucuronidated after cytochrome P450-mediated hydroxylation. In this study, the glucuronidation of Tam and its hydroxylated and/or chlorinated derivatives [4-hydroxytamoxifen (4OHTam), toremifene (Tor), and 4-hydroxytoremifene (4OHTor)] was examined...
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