Article
Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2001
Guillemette C, De Vivo I, Hankinson S E, Haiman C A, Spiegelman D, Housman D E, Hunter D J
Abstract excerpt
UDP-glucuronosyltransferases (UGTs) catalyze the detoxification and the elimination of a large number of endogenous and exogenous compounds in the liver and extrahepatic tissues. One of the UGT1A family members, UGT1A1, is involved in estradiol metabolism and, therefore, represents a candidate gene in breast carcinogenesis. A common insertion/deletion polymorphism in the TATA-box of the promoter region of UGT1A1...
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