Article
Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) and risk of breast cancer.
Breast cancer research and treatment - 1 Jun 2004
Adegoke Olufemi J, Shu Xiao Ou, Gao Yu-Tang, Cai Qiuyin, Breyer Joan, Smith Jeffrey, Zheng Wei
Abstract excerpt
Uridine diphospho-glucuronosyltransferase 1A1 (UGT1A1) is involved in catalyzing estrogen, the hormone that plays a central role in the etiology of breast cancer. A common polymorphism [A(TA)6TAA (allele *1) to A(TA)7TAA change (allele *28)] in the TATA-box of the promoter region of the UGT1A1 gene has been reported to be associated with a reduced transcription of this gene. We investigated the association of...
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