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Article

Promoter length polymorphism in UGT1A1 and the risk of sporadic colorectal cancer.

Cancer genetics - 1 Apr 2012

Bajro Marija Hiljadnikova, Josifovski Toni, Panovski Milco, Jankulovski Nikola, Nestorovska Aleksandra Kapedanovska, Matevska Nadica, Petrusevska Natalija, Dimovski Aleksandar J

Abstract excerpt

Uridine diphosphoglucuronate glucuronosyltransferase 1A1 (UGT1A1) is the key hepatic detoxification enzyme involved in the biotransformation of many carcinogens implicated in the development of colon, breast, and prostate cancers in humans. A polymorphism in the UGT1A1 promoter containing a TA-repeat element [(TA)5-8TAA] is involved in the modulation of UGT1A1 transcriptional activity. The wild-type activity is...

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PMID: 22559977
DOI: 10.1016/j.cancergen.2012.01.015

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