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Article

Genetic variations in UGT1A1 and UGT2B7 and endometrial cancer risk.

Pharmacogenetics and genomics - 1 Mar 2009

McGrath Monica, Lepine Johanie, Lee I-Min, Villeneuve Lyne, Buring Julie, Guillemette Chantal, De Vivo Immaculata

Abstract excerpt

Uridine diphosphate-glucuronosyltransferases (UGTs) are a family of phase II-metabolizing enzymes involved in glucuronic acid conjugation of sex steroid hormones. UGT1A1 and UGT2B7 are expressed in the uterus and involved in the conjugation and elimination of estrogens. Chronic exposure to estrogens is associated with endometrial cancer. Functional polymorphisms have been identified in UGT1A1 and UGT2B7. We...

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Identifiers

PMID: 19352303
DOI: 10.1097/FPC.0b013e328323f66c
PMCID: PMC2667627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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