Genetic mapping using haplotype and model-free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31-33.

doi:10.1002/ajmg.b.20091

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Article

Genetic mapping using haplotype and model-free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31-33.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 Feb 2004

Hong Kyung Sue, McInnes L Alison, Service Susan K, Song Terry, Lucas Jennifer, Silva Sandra, Fournier Eduardo, León Pedro, Molina Julio, Reus Victor I, Sandkuijl Lodewijk A, Freimer Nelson B

Abstract excerpt

We report further evidence for our previous suggestion [Garner et al., 2001: Am J Hum Genet 68:1061-1064] of a locus on 5q predisposing to bipolar I disorder (BP-I) in an extended Costa Rican pedigree. We genotyped additional microsatellite markers in this region and applied a multi-point non-parametric linkage analysis (SimWalk2). Significant identity-by-descent allele sharing among affected relatives was...

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PMID: 14755450
DOI: 10.1002/ajmg.b.20091

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