Article
Genetic mapping using haplotype, association and linkage methods suggests a locus for severe bipolar disorder (BPI) at 18q22-q23.
Nature genetics - 1 Apr 1996
Freimer N B, Reus V I, Escamilla M A, McInnes L A, Spesny M, Leon P, Service S K, Smith L B, Silva S, Rojas E, Gallegos A, Meza L, Fournier E, Baharloo S, Blankenship K, Tyler D J, Batki S, Vinogradov S, Weissenbach J, Barondes S H, Sandkuijl L A
Abstract excerpt
Manic depressive illness, or bipolar disorder (BP), is characterized by episodes of elevated mood (mania) and depression. We designed a multistage study in the genetically isolated population of the Central Valley of Costa Rica to identify genes that promote susceptibility to severe BP (termed BPI), and screened the genome ot two Costa Rican BPI pedigrees (McInnes et al., submitted). We considered only...
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