Article
Combined analysis from eleven linkage studies of bipolar disorder provides strong evidence of susceptibility loci on chromosomes 6q and 8q.
American journal of human genetics - 1 Oct 2005
McQueen Matthew B, Devlin B, Faraone Stephen V, Nimgaonkar Vishwajit L, Sklar Pamela, Smoller Jordan W, Abou Jamra Rami, Albus Margot, Bacanu Silviu-Alin, Baron Miron, Barrett Thomas B, Berrettini Wade, Blacker Deborah, Byerley William, Cichon Sven, Coryell Willam, Craddock Nick, Daly Mark J, Depaulo J Raymond, Edenberg Howard J, Foroud Tatiana, Gill Michael, Gilliam T Conrad, Hamshere Marian, Jones Ian, Jones Lisa, Juo Suh-Hang, Kelsoe John R, Lambert David, Lange Christoph, Lerer Bernard, Liu Jianjun, Maier Wolfgang, Mackinnon James D, McInnis Melvin G, McMahon Francis J, Murphy Dennis L, Nothen Markus M, Nurnberger John I, Pato Carlos N, Pato Michele T, Potash James B, Propping Peter, Pulver Ann E, Rice John P, Rietschel Marcella, Scheftner William, Schumacher Johannes, Segurado Ricardo, Van Steen Kristel, Xie Weiting, Zandi Peter P, Laird Nan M
Abstract excerpt
Several independent studies and meta-analyses aimed at identifying genomic regions linked to bipolar disorder (BP) have failed to find clear and consistent evidence of linkage regions. Our hypothesis is that combining the original genotype data provides benefits of increased power and control over sources of heterogeneity that outweigh the difficulty and potential pitfalls of the implementation. We conducted a...
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