Genetic refinement and physical mapping of a 2.3 Mb probable disease region associated with a bipolar affective disorder susceptibility locus on chromosome 4q35.

doi:10.1002/ajmg.b.10023

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Article

Genetic refinement and physical mapping of a 2.3 Mb probable disease region associated with a bipolar affective disorder susceptibility locus on chromosome 4q35.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Feb 2003

Badenhop Renee F, Moses Melissa J, Scimone Anna, Adams Linda J, Kwok John B J, Jones Anne-Marie, Davison Gail, Evans Mary R, Kirkby Kenneth C, Hewitt Jane E, Donald Jennifer A, Mitchell Philip B, Schofield Peter R

Abstract excerpt

A susceptibility locus for bipolar affective disorder has been mapped to chromosome 4q35 in a large multigenerational pedigree. We have expanded this analysis to include 55 pedigrees (674 individuals, 214 affecteds). The evidence for linkage to 4q35 was strengthened in this larger cohort, with a maximum two-point LOD score of 3.2 for marker D4S1652. Several other markers in the region gave LOD scores greater than...

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PMID: 12555231
DOI: 10.1002/ajmg.b.10023

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