Article
Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate.
American journal of human genetics - 1 Sept 2002
Ophoff Roel A, Escamilla Michael A, Service Susan K, Spesny Mitzi, Meshi Dar B, Poon Wingman, Molina Julio, Fournier Eduardo, Gallegos Alvaro, Mathews Carol, Neylan Thomas, Batki Steven L, Roche Erin, Ramirez Margarita, Silva Sandra, De Mille Melissa C, Dong Penny, Leon Pedro E, Reus Victor I, Sandkuijl Lodewijk A, Freimer Nelson B
Abstract excerpt
Genomewide association studies may offer the best promise for genetic mapping of complex traits. Such studies in outbred populations require very densely spaced single-nucleotide polymorphisms. In recently founded population isolates, however, extensive linkage disequilibrium (LD) may make these studies feasible with currently available sets of short tandem repeat markers, spaced at intervals as large as a few...
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