Article
Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population.
Proceedings of the National Academy of Sciences of the United States of America - 25 Sept 2001
McInnes L A, Service S K, Reus V I, Barnes G, Charlat O, Jawahar S, Lewitzky S, Yang Q, Duong Q, Spesny M, Araya C, Araya X, Gallegos A, Meza L, Molina J, Ramirez R, Mendez R, Silva S, Fournier E, Batki S L, Mathews C A, Neylan T, Glatt C E, Escamilla M A, Luo D, Gajiwala P, Song T, Crook S, Nguyen J B, Roche E, Meyer J M, Leon P, Sandkuijl L A, Freimer N B, Chen H
Abstract excerpt
We have searched for genes predisposing to bipolar disorder (BP) by studying individuals with the most extreme form of the affected phenotype, BP-I, ascertained from the genetically isolated population of the Central Valley of Costa Rica (CVCR). The results of a previous linkage analysis on two extended CVCR BP-I pedigrees, CR001 and CR004, and of linkage disequilibrium (LD) analyses of a CVCR population sample...
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