Article
Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms.
Molecular psychiatry - 1 Jul 2012
Badner J A, Koller D, Foroud T, Edenberg H, Nurnberger J I, Zandi P P, Willour V L, McMahon F J, Potash J B, Hamshere M, Grozeva D, Green E, Kirov G, Jones I, Jones L, Craddock N, Morris D, Segurado R, Gill M, Sadovnick D, Remick R, Keck P, Kelsoe J, Ayub M, MacLean A, Blackwood D, Liu C-Y, Gershon E S, McMahon W, Lyon G J, Robinson R, Ross J, Byerley W
Abstract excerpt
Because of the high costs associated with ascertainment of families, most linkage studies of Bipolar I disorder (BPI) have used relatively small samples. Moreover, the genetic information content reported in most studies has been less than 0.6. Although microsatellite markers spaced every 10 cM typically extract most of the genetic information content for larger multiplex families, they can be less informative...
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