Article
Genome screening for linkage disequilibrium in a Costa Rican sample of patients with bipolar-I disorder: a follow-up study on chromosome 18.
American journal of medical genetics - 8 Mar 2001
Escamilla M A, McInnes L A, Service S K, Spesny M, Reus V I, Molina J, Gallegos A, Fournier E, Batki S, Neylan T, Matthews C, Vinogradov S, Roche E, Tyler D J, Shimayoshi N, Mendez R, Ramirez R, Ramirez M, Araya C, Araya X, Leon P E, Sandkuijl L A, Freimer N B
Abstract excerpt
Linkage disequilibrium (LD) methods offer great promise for mapping complex traits, but have thus far been applied sparingly. In this paper we describe an LD mapping study of severe bipolar disorder (BP-I) in the genetically isolated population of the Central Valley of Costa Rica. This study provides the first complete screen of a chromosome for a complex trait using LD mapping and presents the first application...
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