Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Dec 2003

Ito Nobutoshi, Nureki Osamu, Shirouzu Mikako, Yokoyama Shigeyuki, Hanaoka Fumio

Abstract excerpt

BACKGROUND: In chromosomal DNA replication, DNA primase initiates the synthesis of a dinucleotide on a single-stranded template DNA, and elongates it to form a primer RNA for the replicative DNA polymerase. Although the apo-structure of an archaeal primase has been reported, the mechanism of primer synthesis by the eukaryotic-type primase still remains to be elucidated. RESULTS: In this study, we present the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Primase

Share to Macromolecular Substances

Share to Models, Molecular

Share to Sequence Alignment

Source

Identifiers

PMID: 14750947
DOI: 10.1111/j.1365-2443.2003.00693.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crystal structure of the Pyrococcus horikoshii DNA primase-UTP complex: implications for the mechanism of primer synthesis.PMID 14750947Read ↗

Crystal structure of the human primase.Semantic proximity Read ↗

Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase.Semantic proximity Read ↗

Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I.Semantic proximity Read ↗

Crystal structure and DNA-binding mode of Klebsiella pneumoniae primosomal PriB protein.Semantic proximity Read ↗

Novel ribonucleotide discrimination in the RNA polymerase-like two-barrel catalytic core of Family D DNA polymerases.Semantic proximity Read ↗

Structural mechanism for coordination of proofreading and polymerase activities in archaeal DNA polymerases.Semantic proximity Read ↗

Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymeraseSemantic proximity Read ↗

The closed structure of an archaeal DNA ligase from Pyrococcus furiosus.Semantic proximity Read ↗

Aromatic residues located close to the active center are essential for the catalytic reaction of flap endonuclease-1 from hyperthermophilic archaeon Pyrococcus horikoshii.Semantic proximity Read ↗

Structural Insight into the Specific DNA Template Binding to DnaG primase in Bacteria.Semantic proximity Read ↗

Complexed crystal structure of replication restart primosome protein PriB reveals a novel single-stranded DNA-binding mode.Semantic proximity Read ↗

DNA polymerase α-primase can function as a translesion DNA polymeraseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.