Article

DNA polymerase α-primase can function as a translesion DNA polymerase

2025-07-02

Abstract excerpt

Replication of cellular chromosomes requires a primase to generate short RNA primers to initiate genomic replication. While bacterial and archaeal primase generate short RNA primers, the eukaryotic primase, Polα-primase, contains both RNA primase and DNA polymerase (Pol) subunits that function together to form a >20 base hybrid RNA-DNA primer. Interestingly, the DNA Pol1 subunit of Polα lacks a 3’-5’ proofreading...

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Literature Corpus work: 4661464f-c403-5a1a-a3ac-fdaf7c470636
DOI: 10.1101/2025.07.02.662785

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