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Article

Insights into eukaryotic DNA priming from the structure and functional interactions of the 4Fe-4S cluster domain of human DNA primase.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2010

Vaithiyalingam Sivaraja, Warren Eric M, Eichman Brandt F, Chazin Walter J

Abstract excerpt

DNA replication requires priming of DNA templates by enzymes known as primases. Although DNA primase structures are available from archaea and bacteria, the mechanism of DNA priming in higher eukaryotes remains poorly understood in large part due to the absence of the structure of the unique, highly conserved C-terminal regulatory domain of the large subunit (p58C). Here, we present the structure of this domain...

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Identifiers

PMID: 20643958
DOI: 10.1073/pnas.1002009107
PMCID: PMC2922289

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