Article
Novel ribonucleotide discrimination in the RNA polymerase-like two-barrel catalytic core of Family D DNA polymerases.
Nucleic acids research - 2 Dec 2020
Zatopek Kelly M, Alpaslan Ece, Evans Thomas C, Sauguet Ludovic, Gardner Andrew F
Abstract excerpt
Family D DNA polymerase (PolD) is the essential replicative DNA polymerase for duplication of most archaeal genomes. PolD contains a unique two-barrel catalytic core absent from all other DNA polymerase families but found in RNA polymerases (RNAPs). While PolD has an ancestral RNA polymerase catalytic core, its active site has evolved the ability to discriminate against ribonucleotides. Until now, the mechanism...
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