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Article

The closed structure of an archaeal DNA ligase from Pyrococcus furiosus.

Journal of molecular biology - 28 Jul 2006

Nishida Hirokazu, Kiyonari Shinichi, Ishino Yoshizumi, Morikawa Kosuke

Abstract excerpt

DNA ligases join single-strand breaks in double-stranded DNA, and are essential to maintain genome integrity in DNA metabolism. Here, we report the 1.8 A resolution structure of Pyrococcus furiosus DNA ligase (PfuLig), which represents the first full-length atomic view of an ATP-dependent eukaryotic-type DNA ligase. The enzyme comprises the N-terminal DNA-binding domain, the middle adenylation domain, and the...

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Identifiers

PMID: 16820169
DOI: 10.1016/j.jmb.2006.05.062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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