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Article

Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I.

Nucleic acids research - 18 Aug 2015

Miyazono Ken-Ichi, Ishino Sonoko, Tsutsumi Kanae, Ito Tomoko, Ishino Yoshizumi, Tanokura Masaru

Abstract excerpt

Nucleases play important roles in nucleic acid processes, such as replication, repair and recombination. Recently, we identified a novel single-strand specific 3'-5' exonuclease, PfuExo I, from the hyperthermophilic archaeon Pyrococcus furiosus, which may be involved in the Thermococcales-specific DNA repair system. PfuExo I forms a trimer and cleaves single-stranded DNA at every two nucleotides. Here, we report...

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Identifiers

PMID: 26138487
DOI: 10.1093/nar/gkv654
PMCID: PMC4538837

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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