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Article

Selection on codon bias in yeast: a transcriptional hypothesis.

Nucleic acids research - 1 Nov 2013

Trotta Edoardo

Abstract excerpt

Codons that code for the same amino acid are often used with unequal frequencies. This phenomenon is termed codon bias. Here, we report a computational analysis of codon bias in yeast using experimental and theoretical genome-wide data. We show that the most used codons in highly expressed genes can be predicted by mRNA structural data and that the codon choice at each synonymous site within an mRNA is not random...

Topics

Base Composition
Codon
Codon, Initiator
Codon, Terminator
DNA, Intergenic
Introns
Mutation
Nucleosomes
RNA Folding
RNA, Messenger
RNA, Transfer
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae Proteins

Selection, Genetic

Thermodynamics

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 23945943
DOI: 10.1093/nar/gkt740
PMCID: PMC3814355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-23945943-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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