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Article

Selective forces and mutational biases drive stop codon usage in the human genome: a comparison with sense codon usage.

BMC genomics - 17 May 2016

Trotta Edoardo

Abstract excerpt

BACKGROUND: The three stop codons UAA, UAG, and UGA signal the termination of mRNA translation. As a result of a mechanism that is not adequately understood, they are normally used with unequal frequencies. RESULTS: In this work, we showed that selective forces and mutational biases drive stop codon usage in the human genome. We found that, in respect to sense codons, stop codon usage was affected by stronger...

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Identifiers

PMID: 27188984
DOI: 10.1186/s12864-016-2692-4
PMCID: PMC4869280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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