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Article

Generation of Yersinia pestis attenuated strains by signature-tagged mutagenesis in search of novel vaccine candidates.

Infection and immunity - 1 Feb 2004

Flashner Yehuda, Mamroud Emanuelle, Tidhar Avital, Ber Raphael, Aftalion Moshe, Gur David, Lazar Shirley, Zvi Anat, Bino Tamar, Ariel Naomi, Velan Baruch, Shafferman Avigdor, Cohen Sara

Abstract excerpt

In a search for novel attenuated vaccine candidates for use against Yersinia pestis, the causative agent of plague, a signature-tagged mutagenesis strategy was used and optimized for a subcutaneously infected mouse model. A library of tagged mutants of the virulent Y. pestis Kimberley53 strain was generated. Screening of 300 mutants through two consecutive cycles resulted in selection of 16 mutant strains that...

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Identifiers

PMID: 14742535
DOI: 10.1128/IAI.72.2.908-915.2004
PMCID: PMC321629

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