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Article

Role of a new intimin/invasin-like protein in Yersinia pestis virulence.

Infection and immunity - 1 Oct 2012

Seo Keun Seok, Kim Jong Wan, Park Joo Youn, Viall Austin K, Minnich Scott S, Rohde Harold N, Schnider Darren R, Lim Seung Yong, Hong Joon Bae, Hinnebusch B Joseph, O'Loughlin Jason L, Deobald Claudia F, Bohach Gregory A, Hovde Carolyn J, Minnich Scott A

Abstract excerpt

A comprehensive TnphoA mutant library was constructed in Yersinia pestis KIM6 to identify surface proteins involved in Y. pestis host cell invasion and bacterial virulence. Insertion site analysis of the library repeatedly identified a 9,042-bp chromosomal gene (YPO3944), intimin/invasin-like protein (Ilp), similar to the Gram-negative intimin/invasin family of surface proteins. Deletion mutants of ilp were...

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Identifiers

PMID: 22851752
DOI: 10.1128/IAI.00294-12
PMCID: PMC3457552

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